Lithium Hydroxide → HCID 58005101, compound

Participants

Reaction Conditions

Reaction Steps

A 0.25M solution of methyl N-hex-5-en-1-yl-3-methyl-L-valinate 99 in a mixture of MeOH:water (3:1) was treated with LiOH (3.0 eq.) at RT. The reaction mixture was stirred at 70° C. for 3 h. The organic solvent was removed under reduced pressure and the residue was acidified with aqueous HCl (1N). The water phase was repeatedly extracted with EtOAc, dried (Na2SO4) and concentrated under reduced pressure to afford the crude product, which was used in the following step without further purification. MS (ES+) m/z 214 (M+H)+

Provenance & Evidence