関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| 反応物 | 5,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene | HCID 170361 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Champix | HCID 46783232 | 99.9% |
反応手順
7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino-[2,3-h][3]benzazepine (50 g) was dissolved in methanol (375 ml) and the solution was added to a solution of tartaric acid (39.31 g) dissolved in methanol (375 ml) at 20-25° C. The suspension was stirred for 1 hour 30 minutes at 20-25° C. followed by filtration of the solid and then drying to yield 82 g of varenicline tartrate (Purity by HPLC: 99.9%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08314235B2 |
|---|
| 出典データセット | uspto-grants-2012_11 |
|---|
| ORD ID | ord-4b9bbe76b2124621bd49fff88507b42a |
|---|
| 出典メモ | uspto-grants-2012_11 |
|---|
