3-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid → 3-(4-(Trifluoromethyl)phenyl)propionic Acid

HRID 1879319Notes

Reaction equation

HRID 1879319 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1>CO.[Pd]>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[CH:12][CH:13]=1

Participants

4

Reactant 1

HCID 749403-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid2×

Product 1

HCID 35887363-(4-(Trifluoromethyl)phenyl)propionic Acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-trifluoromethylcinnamic acid (commercial available) in methanol is hydrogenated with Pd/C (5 wt %) at 2 bar until 4-trifluoromethylcinnamic acid has reacted completely. After removal of the catalyst by filtration the 4-trifluoromethylhydrocinnamic acid is further reacted in step 2 to compound 2.

Workup

  1. customhas reacted completely
  2. customAfter removal of the catalyst
  3. filtrationby filtration the 4-trifluoromethylhydrocinnamic acid
  4. customis further reacted in step 2 to compound 2

Sources & evidence

ORD record
ord-44a15e9d9d724f37850101598ed1c500
Source dataset
uspto-grants-2012_11
Patent number
US08314238B2

Reaction notes

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