HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Phenylenediamine → HCID 67357285, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Carbobenzoxy-4-piperidinecarboxylic Acid | HCID 736489 | — |
| Reactant | PyBOP | HCID 2724699 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67357285 | HCID 67357285 | 212.9% |
Reaction Steps
A mixture of 3.5 g of piperidine-1,4-dicarboxylic acid monobenzyl ester, 1.5 g of phenylendiamine, 2.3 mL of DIPEA and 6.9 g of PyBOP in 40 mL of DCM was stirred overnight at rt. The reaction was quenched with H2O, extracted with DCM, dried over MgSO4 and concentrated in vacuo to obtain 10 g of the desired compound as crude brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314253B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-57c69664e00e4c62a05000d082066936 |
| Source note | uspto-grants-2012_11 |