HCID 67357285, compound → HCID 22029065, compound

Participants

Reaction Conditions

Reaction Steps

A solution of crude 10 g of 4-(2-amino-phenylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester was dissolved in 200 mL glacial AcOH and heated to 90° C. for 1.5 h. The reaction mixture was evaporated to dryness, redissolved in 20 mL MeOH and concentrated in vacuo. Purification by CC with EtOAc/Hept (9:1) to EtOAc yielded 1.3 g of the desired compound as beige solid.

Provenance & Evidence