Hydrogen chloride-ethyl acetate → ethyl 5-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}pyrazine-2-carboxylate trihydrochloride

Participants

Reaction Conditions

Reaction Steps

690 mg of ethyl 5-[({6-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]pyrazine-2-carboxylate was dissolved in 7.00 mL of ethyl acetate, and 4.17 mL of a 4 M hydrogen chloride/ethyl acetate solution was added thereto, followed by stirring at 50° C. for 3 hours. The reaction liquid was concentrated under reduced pressure, and the obtained residue was solidified by the addition of isopropanol to obtain 712 mg of ethyl 5-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}pyrazine-2-carboxylate trihydrochloride.

Provenance & Evidence