Propylene Oxide → HCID 58398406, compound

Participants

Reaction Conditions

Reaction Steps

680 mg of methyl 4-({4,5-dimethyl-2-[(pyridin-2-ylsulfonyl)amino]phenoxy}methyl)benzoate was dissolved in 6.45 mL of pyridine, and 1.13 mL of 2-methyloxirane was added thereto, followed by stirring at 80° C. overnight in a sealed tube. The reaction liquid was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (chloroform:methanol=100:1 to 99:1) to obtain 466 mg of methyl 4-({2-[(2-hydroxypropyl)(pyridin-2-ylsulfonyl)amino]-4,5-dimethylphenoxy}methyl)benzoate.

Provenance & Evidence