反应详情

4.20 g of 5-(methoxymethoxy)-6-nitroindane was dissolved in 42.0 mL of methanol, and 500 mg of 10% palladium carbon was added thereto, followed by stirring at room temperature for 6 hours under a hydrogen atmosphere. After the catalyst was removed by filtration, the filtrate was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to obtain 3.30 g of 6-(methoxymethoxy)indan-5-amine.

1. customAfter the catalyst was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1)