Sodium Hydroxide → HCID 58398428, compound

Participants

Reaction Steps

148 mg of methyl 6-[({6-[(2-fluoropropyl)(pyridin-3-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]nicotinate was dissolved in 3.00 mL of THF and 1.50 mL of methanol, and 1.50 mL of a 1 M aqueous sodium hydroxide solution was added thereto, followed by stirring overnight at room temperature. The reaction liquid was concentrated under reduced pressure, and to the obtained residue was added a 5% w/v aqueous citric acid solution, followed by extraction with chloroform. The organic layer was concentrated under reduced pressure, and the obtained crude product was crystallized by the addition of isopropanol/diisopropyl ether, collected by filtration, and dried under reduced pressure to obtain 79 mg of 6-[({6-[(2-fluoropropyl)(pyridin-3-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]nicotinic acid.

Provenance & Evidence