反应详情

温度

0 °C

To a stirred, cold (0° C.) solution of 4-bromo-1-fluoro-2-nitrobenzene (7 g, 32 mmol) in dichloromethane (100 mL) was added isopropylamine (5 mL, 64 mmol). The mixture was allowed to stir at 0° C. for 3 h and room temperature overnight. It was diluted with water and extracted with CH2Cl2. The organic layer was washed with water and brine, dried (MgSO4), and filtered. The filtrate was concentrated in vacuo to give a crude red solid. Trituration with MeOH afforded the title compound as an orange-red solid. MS (ESI, pos. ion) m/z: 260.7 (M+1).

1. extractionextracted with CH2Cl2
2. washThe organic layer was washed with water and brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationThe filtrate was concentrated in vacuo
6. customto give a crude red solid