4-Phenylpiperidine → HCID 52952850, compound

Participants

Reaction Steps

2-(3-{[(6-Chloro-2-fluoro-3-methoxy-benzyl)-((S)-1 dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid (Intermediate 7, 0.065 g, 0.108 mmol) was reacted with 4-phenylpiperidine (available from Aldrich Chemical Company, Inc., 1001 West Saint Paul Avenue, Milwaukee, Wis. 53233, USA; 0.023 g, 0.140 mmol) to form [2-(3-{[(6-chloro-2-fluoro-3-methoxy-benzyl)-((S)-1-dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidin-3-yl]-(4-phenyl-piperidin-1-yl)-methanone (0.018 g, 23%). m/z=741 (M+1); HRMS: calcd for C40H55ClFN4O4S. Calc [M+H+] 741.3611. found 741.3611.

Provenance & Evidence