4-Chlorobenzylamine → HCID 52952852, compound

Participants

Reaction Steps

2-(3-{[(6-Chloro-2-fluoro-3-methoxy-benzyl)-((S)-1 dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid (Intermediate 7, 0.085 g, 0.142 mmol) was reacted with 4-chlorobenzyl amine (available from Aldrich Chemical Company, Inc., 1001 West Saint Paul Avenue, Milwaukee, Wis. 53233, USA; 43 μL, 0.355 mmol) to form 2-(3-{[(6-chloro-2-fluoro-3-methoxy-benzyl)-((S)-1-dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid 4-chloro-benzylamide (0.038 g, 37%). m/z=721 (M+1); HRMS: calcd for C36H48Cl2FN4O4S. Calc [M+H+] 721.2752. found 721.2755.

Provenance & Evidence