4-(4-Chlorophenyl)-4-hydroxypiperidine → HCID 58280468, compound

Participants

Reaction Steps

2-(3-{[(6-Chloro-2-fluoro-3-methoxy-benzyl)-((S)-1 dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid (Intermediate 7, 0.081 g, 0.135 mmol) was reacted with 4-(4-chlorophenyl)-4-hydroxypiperidine (available from Aldrich Chemical Company, Inc., 1001 West Saint Paul Avenue, Milwaukee, Wis. 53233, USA; 0.035, 0.166 mmol) to form [2-(3-{[(6-Chloro-2-fluoro-3-methoxy-benzyl)-((S)-1-dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidin-3-yl]-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-methanone (0.066 g, 62%). m/z=791 (M+1); HRMS: calcd for C40H54Cl2FN4O5S. Calc [M+H+] 791.3171. found 791.3169.

Provenance & Evidence