N-(7-(benzyloxy)-9H-carbazol-2-yl)-N-methylformamide → N-(7-hydroxy-9H-carbazol-2-yl)-N-methylformamide

HRID 1879539노트

반응식

HRID 1879539 반응식
C([O:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([N:22]([CH3:25])[CH:23]=[O:24])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([N:22]([CH3:25])[CH:23]=[O:24])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1

참가 물질

4

반응물 1

HCID 86651370N-(7-(benzyloxy)-9H-carbazol-2-yl)-N-methylformamide

생성물 1

HCID 58225218N-(7-hydroxy-9H-carbazol-2-yl)-N-methylformamide수율 94.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To N-(7-(benzyloxy)-9H-carbazol-2-yl)-N-methylformamide (110 mg, 0.33 mmol) in 50 mL MeOH was added Palladium on activated carbon (50 mg). The mixture was stirred at rt under H2 atmosphere for 15 h. Solid was filtered off and the filtrate was concentrated to afford N-(7-hydroxy-9H-carbazol-2-yl)-N-methylformamide as a brown solid (75 mg, 94%). This material was used directly for the next reaction without purification. MS (ESI) m/z 241 (M+H+).

후처리

  1. filtrationSolid was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-ad33f236729740c284b550baf51246f4
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318132B2

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