Ethyl Acetate → HCID 58160187, compound

Participants

Reaction Steps

To 4-(benzyloxy)-1-chloro-2-nitrobenzene (394 mg, 1.5 mmol) N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)formamide (370 mg, 1.5 mmol) in 6 mL dioxane was added 3 mL of a 1 M Na2CO3 (aq) solution and Tetrakis(triphenylphosphine)palladium (52 mg, 0.045 mmol). The suspension was headed at reflux for 15 h under Ar atmosphere and cooled to rt. It was added EtOAc (80 mL) and washed with brine (50 mL), water (2×80 mL), and dried over MgSO4. After solvent removal, the residue was chromatographed (hexane/EtOAc) to afford N-(4′-(benzyloxy)-2′-nitrobiphenyl-4-yl)formamide as a yellow solid (395 mg, 75%). MS (ESI) m/z 349 (M+H+).

Provenance & Evidence