HCID 59283052, compound → N-(7-hydroxy-9H-carbazol-2-yl)formamide

HRID 1879545Notes

Reaction equation

HRID 1879545 reaction equation
C([O:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([NH:22][CH:23]=[O:24])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([NH:22][CH:23]=[O:24])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 59283052HCID 59283052, compound

Product 1

HCID 58160250N-(7-hydroxy-9H-carbazol-2-yl)formamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To N-(7-(benzyloxy)-9H-carbazol-2-yl)formamide (250 mg, 0.79 mmol) in 50 mL MeOH was added Palladium on activated carbon (60 mg). The mixture was stirred at rt under H2 atmosphere for 15 h. The mixture was concentrated under reduced pressure and dried under high vacuum to afford N-(7-hydroxy-9H-carbazol-2-yl)formamide mixed with the catalyst as a black solid (240 mg). This material was used directly for the next reaction without purification. MS (ESI) m/z 227 (M+H+).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-69f81d402d5b4d06a90612cc5179fc96
Source dataset
uspto-grants-2012_11
Patent number
US08318132B2

Reaction notes

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