Hydrochloric Acid → HCID 178503712, compound

Participants

Reaction Steps

Add 4M hydrogen chloride in 1,4-dioxane (19.35 mL, 77.38 mmol) dropwise to a solution of (1R,2S,4R,5R,6R)-2-[[(2S)-2-(tert-butoxycarbonylamino)-4-methylsulfanyl-butanoyl]amino]-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (2.66 g, 5.16 mmol) in 1,4-dioxane (26.6 mL) at room temperature in a water bath, and maintain stirring overnight at room temperature. Add methyl-t-butyl ether (200 mL) and stir the mixture for 2 hours. Filter the solid and dry in vacuo overnight. Redissolve the material in water and freeze-dry overnight. Triturate the solid in acetone (10 volumes) at reflux, filter and dry in vacuo under nitrogen for 48 hours to give the title compound (2.33 g, 5.16 mmol) as a white solid. MS (m/z): 416 (M+1).

Provenance & Evidence