7-Epi-Taxol → HCID 131730074, compound

Participants

Reaction Steps

A solution of paclitaxel/7-epipaclitaxel conjugate was prepared by accurately weighting 350±5 mg of the conjugate in a 10 mL flask and dissolving with dimethylsulfoxide. The solution was diluted to volume with the same solvent. 250±2.5 mg of PPX (Pharmaceutical Grade) were accurately weighed in a 5 mL flask. 0.085 mL of the spiking solution (corresponding to a spiking level of 1.2% w/w) was added in the same flask and diluted to volume with dimethylsulfoxide. The aminolysis reaction was then performed according to the general procedure given in Example 2 and analysed by HPLC. Recovery of 7-epipaclitaxel was 110.7%.

Provenance & Evidence