反应详情

温度

110 °C

A mixture of 1,1,2-trimethyl[1H]-benz[e]indole (10.0 g, 47.8 mmol) and 3-bromopropanoic acid (7.3 g, 47.8 mmol) in 1,2-dichlorobenzene (50 mL) was heated with stirring at 110° C. for 18 h. After the resulting mixture was cooled to room temperature, the precipitated was collected by filtration, triturated with DCM thoroughly, and dried under vacuum to afford 15.2 g of light brown powder (88%). ESI-MS: observed for [MH]+281.31.

1. temperaturewas heated
2. temperatureAfter the resulting mixture was cooled to room temperature
3. filtrationthe precipitated was collected by filtration
4. customtriturated with DCM thoroughly
5. customdried under vacuum