Trifluoroacetic acid → HCID 46893526, compound

Participants

Reaction Steps

To a solution of the slower-eluting enantiomer of the product from Step B (4.6 mg, 0.0069 mmol) in DCM (1 mL) was added TFA (1 mL, 13 mmol), and the solution was stirred for 30 minutes at RT. The solution was concentrated, then the residue was purified by reverse phase HPLC eluting with acetonitrile/water+0.1% TFA. Following lyophilization, this afforded the enantiopure title compound as a white solid. 1H NMR (500 MHz, CD3OD): δ 7.92 (s, 1H); 7.62 (d, J=8.5 Hz, 2H); 7.53 (d, J=8.3 Hz, 2H); 7.43 (s, 1H); 7.36 (d, J=8.2 Hz, 2H); 7.33 (d, J=8.5 Hz, 2H); 4.78 (d, 3=11.5 Hz, 1H); 4.26 (s, 3H); 3.72 (td, J=11.4, 3.2 Hz, 1H); 3.52 (t, J=6.9 Hz, 2H); 2.55 (t, J=6.9 Hz, 2H); 1.68-1.57 (m, 1H); 1.50-1.43 (m, 1H); 1.05-0.97 (m, 2H); 0.73 (t, J=7.3 Hz, 3H); LC2 1.31 min. (M+H)+ 606.

Provenance & Evidence