Hydrazine hydrate (1:1) → HCID 178440966, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the minor diastereomer of tert-butyl N-(4-{1-[2-[3-chloro-2-fluoro-5-(trifluoromethyl)phenyl]-1-(4-chlorophenyl)-2-oxoethyl]butyl}benzoyl)-β-alaninate (EXAMPLE 2, Step A, 71 mg, 0.108 mmol) in pyridine (5 mL) was added hydrazine hydrate (0.053 mL, 1.1 mmol). The mixture was stirred at 80° C. for one hour in a sealed tube. The mixture was diluted with 1 N HCl (aq), then extracted twice with EtOAc. The combined organic layers were dried over sodium sulfate, filtered, then concentrated to afford the title compound. This material was used directly in the next step without further purification. LC2 1.57 min. (M-tBu+H)+ 592.

Provenance & Evidence