Hydrazine hydrate (1:1) → HCID 178440959, compound

Participants

Reaction Steps

To a solution of the product of Step F (600 mg, 0.925 mmol) in DMSO (10 mL) was added hydrazine hydrate (60 wt %, 2.0 mL, 24 mmol). The mixture was stirred at room temperature until all starting ketone had been consumed by LC-MS analysis. The mixture was diluted with ethyl acetate then washed with saturated NaCl (aq). The organic layer was dried over sodium sulfate, filtered, then concentrated. The resulting residue was purified by silica gel chromatography eluting with 0-50% EtOAc/hexanes to afford the title compound as a solid. LC2 1.40 min. (M+H)+644.

Provenance & Evidence