HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1879644Generated: October 30, 2026
Dimethylformamide → 8-(3-Methoxy-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
https://huagongshe.com/reaction/1879644
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | 5-Fluoro-2-nitroanisole | HCID 2779250 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-(3-Methoxy-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane | HCID 57443733 | 91.4% |
Reaction Steps
To a mixture of 4-fluoro-2-methoxy-1-nitrobenzene (5 g), potassium carbonate (10 g) and N,N-dimethylformamide (50 mL), 1,4-dioxa-8-azaspiro[4.5]decane (5 g) was added and stirred overnight at 70° C. The reaction mixture was diluted with water (150 mL), and the precipitated solid was collected by filtration and washed with diethyl ether to give 8-(3-methoxy-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane (7.86 g) as a light-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08318702B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-10166b3b7a2e4ae08f5a5709675e906e |
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| Source note | uspto-grants-2012_11 |
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