HCID 67002857, compound → HCID 86761685, compound

Participants

Reaction Steps

To a solution of [2-Bromo-5-(indole-1-sulfonyl) phenyl] methanol (4.73 grams, 12.92 mmol) (obtained from preparation 2) in ethylene dichloride (75 mL) was added manganese dioxide (8.92 grams, 102.5 mmol). The reaction mass was heated to reflux temperature and maintained under reflux for 3 hours while monitoring the progress of the reaction by TLC. After completion of the reaction, the reaction mass was filtered through hyflow bed and the bed was washed with ethylene dichloride (2×10 mL). The clear filtrate was concentrated under reduced pressure to obtain technical product. The technical material was triturated with of n-hexane (2×15 mL), decanted the solvent and dried under reduced pressure to obtain 3.42 grams title product.

Provenance & Evidence