HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluorobenzoic acid → 1-Methyl-4-nitrosopiperidin-4-yl 2,4-difluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluorobenzoic acid | HCID 74102 | — |
| Reactant | 1-Methylpiperidin-4-one oxime | HCID 339053 | — |
| Reactant | HCID 178418268 | HCID 178418268 | — |
| Product | 1-Methyl-4-nitrosopiperidin-4-yl 2,4-difluorobenzoate | HCID 57954497 | — |
Reaction Steps
1-Methyl-4-nitrosopiperidin-4-yl 2,4-difluorobenzoate was prepared from 1-methyl-piperidin-4-one oxime, lead tetraacetate and 2,4-difluorobenzoic acid using conditions of General Method 3. 1H NMR (400 MHz, chloroform-d) δ 7.59 (2H, dd, 7.5, 2.3 Hz), 7.09 (1H, tt, 8.6, 2.4 Hz), 2.98 (2H, dt, 11.7, 3.6 Hz), 2.32-2.50 (7H, m), 2.04 (2H, dd, 14.2, 2.7 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318705B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-1eed22c0b45144449688068e39867685 |
| Source note | uspto-grants-2012_11 |