4,4,4-Trifluorobutanoic acid → 4-Nitrosotetrahydro-2H-pyran-4-yl 4,4,4-trifluorobutanoate

Participants

Role	Name	HCID	Charge
Reactant	4,4,4-Trifluorobutanoic acid	HCID 2777085	—
Reactant	N-(oxan-4-ylidene)hydroxylamine	HCID 12298558	—
Reactant	HCID 178418268	HCID 178418268	—
Product	4-Nitrosotetrahydro-2H-pyran-4-yl 4,4,4-trifluorobutanoate	HCID 57954490	—

Reaction Steps

4-Nitrosotetrahydro-2H-pyran-4-yl 4,4,4-trifluorobutanoate was prepared from tetrahydro-pyran-4-one oxime, lead tetraacetate and 4,4,4-trifluorobutyric acid using conditions of General Method 3. 1H NMR (250 MHz, chloroform-d) δ 3.91-4.19 (2H, m), 3.48-3.83 (2H, m), 2.71-2.94 (2H, m), 2.36-2.67 (2H, m), 2.15-2.34 (2H, m), 1.63-1.96 (2H, m).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08318705B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-5631052d2fef4ba18d4e4885ef97abdb
Source note	uspto-grants-2012_11