Morpholine → HCID 10891583, compound

HRID 1879816Notes

Reaction equation

HRID 1879816 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4](Cl)[N:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>O1CCOCC1.O>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[C:4]([N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)[N:3]=[C:2]2[NH2:1]

Participants

5

Reactant 2

HCID 8083MorpholineHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamine

Product 1

HCID 10891583HCID 10891583, compoundYield 94.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
85 °C

Procedure

To solution of 4-amino-2-chloro-6,7-dimethoxyquinazoline (0.240 g, 1 mmol) in 10 ml dioxane was added morpholine (0.350 ml, 4 mmol). The mixture was heated at 85° C. for 4 h. After cooling to room temperature, the reaction mixture was diluted with water and solid was precipitated. The resulting precipitate was collected by filtration and washed with water and little amount of methanol and to give A 6,7-dimethoxy-2-morpholin-4-yl-quinazolin-4-ylamine (0.275 g) in 94% yield.

Workup

  1. temperatureAfter cooling to room temperature
  2. customwas precipitated
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with water and little amount of methanol

Sources & evidence

ORD record
ord-daa537dd94734328bc3df4fc48b600ee
Source dataset
uspto-grants-2012_11
Patent number
US08318730B2

Reaction notes

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