HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → Methyl 7-(acetylamino)-6-chloro-1,3-benzodioxole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | Methyl 7-(acetylamino)-1,3-benzodioxole-4-carboxylate | HCID 22662748 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 7-(acetylamino)-6-chloro-1,3-benzodioxole-4-carboxylate | HCID 22662759 | 87% |
Reaction Steps
A mixture of intermediate (2-c) (18.5 g) and NCS (11.4 g) in ACN (130 ml) was stirred and refluxed for one hour. The reaction mixture was cooled. The precipitate was filtered off, washed with ACN, with DIPE, then dried, yielding 18.2 g (87%) of methyl 7-(acetylamino)-6-chloro-1,3-benzodioxole-4-carboxylate (intermediate 2-d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318742B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-366113f64af647e9a3da4591d3f13bab |
| Source note | uspto-grants-2012_11 |