HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-[(4-chlorophenyl)methyl]piperidine-4-carboxylic acid | HCID 18968996 | — |
| Reactant | HCID 59327480 | HCID 59327480 | — |
| Product | Ammonia | HCID 222 | — |
| Product | HCID 59327452 | HCID 59327452 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of 4-benzyl-piperidine-4-carboxylic acid (pyridin-3-ylmethyl)-amide; hydrochloride (intermediate 1) the title compound was prepared from 4-(4-chloro-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (commercially available) and benzylamine (commercially available) with subsequent cleavage of the protecting group under acidic conditions. The title compound was purified on silica eluting with a gradient formed from DCM and 2N NH3 and methanol. MS (m/e): 236.1/343.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318749B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-613293ea3f204604acc0954c79c9f14e |
| Source note | uspto-grants-2012_11 |