Hydrochloric Acid → HCID 59327476, compound

Participants

Reaction Steps

In analogy to the procedure described for the synthesis of 4-benzyl-piperidine-4-carboxylic acid (pyridin-3-ylmethyl)-amide; hydrochloride (intermediate 1) the title compound was prepared from 4-(4-chloro-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (commercially available) and 2-chloro-benzylamine (commercially available) with subsequent cleavage of the protecting group under acidic conditions. The title compound was purified on silica eluting with a gradient formed from DCM and methanol and the free base was liberated under basic conditions. MS (m/e): 377.1 (MH+).

Provenance & Evidence