HCID 178513424, compound → HCID 58148007, compound

HRID 1879934Notes

Reaction equation

HRID 1879934 reaction equation
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[N:13]2[CH:16]=[C:17]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[CH:18]=[CH:19][C:12]2=[N:11][C:10]=1[C:26]([NH:28][O:29][C:30](=O)[CH2:31][C:32]1[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=1)=[NH:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]1[C:14](=[O:15])[N:13]2[CH:16]=[C:17]([N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[CH:18]=[CH:19][C:12]2=[N:11][C:10]=1[C:26]1[N:27]=[C:30]([CH2:31][C:32]2[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=2)[O:29][N:28]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 178513424HCID 178513424, compound

Product 1

HCID 58148007HCID 58148007, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The solution of the product of example 21 (261 mg, 0.49 mmol) in toluene (5 ml) was heated at reflux for 2 h. After cooled to room temperature, the solids were collected by filtration, washed with diethyl ether and dried to give the titled product (190 mg, yield 75.3%).

Workup

  1. temperatureat reflux for 2 h
  2. filtrationthe solids were collected by filtration
  3. washwashed with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-118a29e77e244360ab4a8e084d1a28af
Source dataset
uspto-grants-2012_11
Patent number
US08318732B2

Reaction notes

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