Azane;hydrate → HCID 58147983, compound

HRID 1879945Notes

Reaction equation

HRID 1879945 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7]2[C:23]([N:24]3[CH2:28][CH2:27][N:26]([CH3:29])[C:25]3=[O:30])=[CH:22][C:21]([N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)=[CH:20][N:8]2[C:9](=[O:19])[C:10]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O.O.[NH3:38]>>[CH2:12]([O:11][C:10]1[C:9](=[O:19])[N:8]2[CH:20]=[C:21]([N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[CH:22]=[C:23]([N:24]3[CH2:28][CH2:27][N:26]([CH3:29])[C:25]3=[O:30])[C:7]2=[N:6][C:5]=1[C:3]([NH2:38])=[O:2])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 12896473Azane;hydrateHCID 58148070HCID 58148070, compound

Product 1

HCID 58147983HCID 58147983, compoundYield 62%

Conditions

Temperature
40 °C

Procedure

3-Benzyloxy-9-(3-methyl-2-oxo-imidazolidin-1-yl)-7-morpholin-4-yl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid methyl ester (example 221, 1 g, 2.03 mmol) was mixed with ammonia water (28%, 50 ml) and the mixture was heated at 40° C. overnight. The precipitates were collected by filtration and dried in vacuo to give the titled compound (600 mg, 62%).

Workup

  1. filtrationThe precipitates were collected by filtration
  2. customdried in vacuo

Sources & evidence

ORD record
ord-01cf5fb356a04ff28502b5b0935f7ffa
Source dataset
uspto-grants-2012_11
Patent number
US08318732B2

Reaction notes

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