反应详情

温度

50 °C

6-Acetoxy-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline hydrochloride from step 1 (8.72 g, 21.9 mmol) was dissolved in methanol (200 ml). Concentrated aqueous ammonia (15 ml) was added, and the solution heated to 50° C. with stirring for 2 hours, causing precipitation of a cream coloured solid. The solid was collected by filtration, washed with diethyl ether (3×200 ml), and dried in vacuo at 60° C. over diphosphorous pentoxide, giving the product as an off white solid (5.40 g, 77%);

1. customprecipitation of a cream
2. filtrationThe solid was collected by filtration
3. washwashed with diethyl ether (3×200 ml)
4. dry with materialdried in vacuo at 60° C. over diphosphorous pentoxide