反应详情

温度

150 °C

A mixture of methyl 2-(4-hydroxyphenyl)acetate (40.0 g, 241 mmol) and benzene-1,2-diamine (26.0 g, 241 mmol) in a sealed vessel was heated to 150° C. for 18 h. After cooling to room temperature, the mixture was diluted with MeOH and heated to 100 C for 1 h. The mixture was cooled to −20 C overnight, then filtered to collect 25.8 g (48%) of a lavender solid. MS (ESI, pos. ion) m/z: 225 (M+1).

1. temperatureAfter cooling to room temperature
2. temperatureheated to 100 C for 1 h
3. temperatureThe mixture was cooled to −20 C overnight
4. filtrationfiltered
5. customto collect 25.8 g (48%) of a lavender solid