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O,O-Dipyridin-2-yl carbonothioate → 2-(4-Isothiocyanatophenoxy)-3-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O,O-Dipyridin-2-yl carbonothioate | HCID 719784 | — |
| 反応物 | 4-[(3-methyl-2-pyridinyl)oxy]Benzenamine | HCID 59326808 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(4-Isothiocyanatophenoxy)-3-methylpyridine | HCID 59326937 | — |
反応手順
In a round bottomed flask were added 4-(3-methylpyridin-2-yloxy)benzenamine (100 mg, 0.5 mmol), O,O-dipyridin-2-yl carbonothioate (122 mg, 0.52 mmol) and DCM (2 mL). The reaction mixture was stirred at RT for 16 h. The reaction was partitioned between DCM and water, brine. The aqueous layer was extracted with DCM and the combined organics was dried (Na2SO4) and concentrated to give 2-(4-isothiocyanatophenoxy)-3-methylpyridine as tan solid. MS (ESI, pos. ion) m/z: 243.1 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08318718B2 |
| 出典データセット | uspto-grants-2012_11 |
| ORD ID | ord-7b96d52b347a4b4dbe518346b9cca9f2 |
| 出典メモ | uspto-grants-2012_11 |