4-(2-fluoropyridin-3-yl)-1-methyl-5,6-dihydropyridin-2(1H)-one → 4-(2-Fluoropyridin-3-yl)-1-methylpiperidin-2-one

関与物質

反応手順

A solution of 4-(2-fluoropyridin-3-yl)-1-methyl-5,6-dihydropyridin-2(1H)-one (0.067 g, 0.325 mmol) in tetrahydrofuran (1.6 mL) was added palladium, 10 wt. % on activated carbon (0.035 g, 0.032 mmol) and hydrogenated (double-walled balloon pressure) at 40° C. for 3 h. The mixture was filtered via a pad of Celite, and the filtrate was concentrated in vacuo to give a relatively pure crop of 4-(2-fluoropyridin-3-yl)-1-methylpiperidin-2-one as a milky oil. [M+1]=209.0.

情報源と証拠