HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone → 4-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylpiperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone | HCID 59326874 | — |
| Reactant | 4-(2-Fluoropyridin-3-yl)-1-methylpiperidin-2-one | HCID 59327010 | — |
| Product | 4-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylpiperidin-2-one | HCID 59327137 | — |
Reaction Steps
The title compound was prepared from 4-(2-fluoropyridin-3-yl)-1-methylpiperidin-2-one (Step 3, Example 1) and (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone by following the procedure described in Step 4 of Example 1. MS (ESI, pos. ion) m/z: 427.1 (M+1). IC50 (uM) +++++.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318718B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-8288479fc6d44cf2bc894da186a76bca |
| Source note | uspto-grants-2012_11 |