Sodium Hydroxide → HCID 59326812, compound

Participants

Reaction Steps

To the solution of ethyl 2-(4-(1H-benzo[d]imidazole-2-carbonyl)Phenoxy)nicotinate (12.0 g, 30.9 mmol) in methanol (100 mL) was added aqueous solution of NaOH (1.85 g, 46.3 mmol, 30 mL). The reaction mixture was heated up to reflux for 1 h. The reaction mixture was concentrated, diluted with water and filtered. The aqueous layer was washed with ethyl acetate and acidified by addition of 2N HCl to pH 6. The brown precipitate was collected by filtration, dried to give the title compound. MS (ESI, pos. ion) m/z: 360.1 (M+1).

Provenance & Evidence