Ethyl chloroformate → HCID 58138315, compound

Participants

Reaction Steps

Using the procedure of Example 2, 4-amino-5-fluoro-pyrimidin-2-ol (0.25 g, 1.9 mmol), BSA (1.41 mL, 5.8 mmol) and ethyl chloroformate (0.277 mL, 2.9 mmol) were reacted, and the resulting material was purified via reverse phase chromatography (gradient, CH3CN/H2O) to give ethyl 4-amino-5-fluoro-2-oxopyrimidine-1(2H)-carboxylate (0.098 g, 25.6%) as a white solid: mp 190-193° C.; 1H NMR (300 MHz, DMSO-d6) δ 8.29 (s, 1H), 8.04-8.01 (m, 2H), 4.27 (q, J=7.25 Hz, 2H), 1.26 (t, J=7.25 Hz, 3H); ESIMS m/z 200 ([M−H]−).

Provenance & Evidence