Isopropyl chloroformate → HCID 58138312, compound

Participants

Reaction Steps

Using the procedure of Example 2, 4-amino-5-fluoro-pyrimidin-2-ol (0.25 g, 1.9 mmol), BSA (1.41 mL, 5.8 mmol) and isopropyl chloroformate (1 M solution in toluene; 2.9 mL, 2.9 mmol) were reacted, and the resulting material was purified via reverse phase chromatography (gradient, CH3CN/H2O) to give isopropyl 4-amino-5-fluoro-2-oxopyrimidine-1(2H)-carboxylate (0.225 g, 55%) as a white solid: mp 217-219° C.; 1H NMR (300 MHz, DMSO-d6) δ 8.28 (s, 1H), 8.02-7.99 (m, 2H), 4.97 (septet, J=6.26 Hz, 1H), 1.28 (d, J=6.26 Hz, 6H); ESIMS m/z 216 ([M+H]+).

Provenance & Evidence