HCID 67540338, compound → HCID 67539623, compound

Participants

Reaction Steps

To a stirred solution of (3SR,4RS)-4-(3,4-Dichloro-phenyl)-1-(4-methanesulfonyl-piperazine-1-carbonyl)-pyrrolidine-3-carbonitrile (0.1 g, 0.23 mmol) in tetrahydrofuran (1.0 mL) at 0° C. was added BH3 in tetrahydrofuran (0.55 mL, 0.55 mmol). After 2 hours of stirring at ambient temperature the reaction mixture was quenched with MeOH and the volatiles were removed under vacuo. The residue was taken up in H2O, extracted with EtOAc and the combined organic phases were dried over Na2SO4. Flash chromatography (SiO2, EtOAc, then CH2Cl2/MeOH 19:1) yielded the title product (0.57 g, 56%) as a colorless oil. ES-MS m/e: 436.1 (M+H+).

Provenance & Evidence