Water → HCID 67532161, compound

Participants

Reaction Steps

(3SR,4RS) 1-Benzyl-4-(4-chloro-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester (CAS RN: 80896-63-5) (30 g, 0.087 mol) were dissolved in THF (400 mL). At 0° C. LiAlH4 (3.5 g, 0.092 mol) was added portion wise. After stirring at 0° C. for 4 h water (18 mL), then 5N NaOH (18 mL) and additional water (54 mL) was added. After stirring at ambient temperature for 1 h the mixture was extracted with ethyl acetate (3×100 mL), the combined organic phases were dried on sodium sulfate, filtered and evaporated. The crude title product was obtained as a white solid (24.6 g, 93%) and directly used in the next step.

Provenance & Evidence