Methylamine → HCID 68484588, compound

Participants

Reaction Conditions

Reaction Steps

(3SR,4RS) Toluene-4-sulfonic acid-1-benzyl-4-(4-fluoro-phenyl)-pyrrolidin-3-ylmethyl ester (5.0 g, 0.011 mmol) were dissolved in 2.0 M solution of MeNH2 in THF (36 mL) in an autoclave and heated to 80° C. over night. The volatiles were removed and the crude product subjected to column chromatography (silica gel, dichloro methane, dichloro methane/methanol −>4:1) to yield the title compound (2.6 g, 76%) as a light yellow oil.

Provenance & Evidence