Sulfuric Acid → (3S,4S)-1-Benzyl-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid methyl ester

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Reaction Conditions

Reaction Steps

(3S,4S)-1-Benzyl-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid (CAS RN: 907184-53-6) (35.7 g, 0.102 mol) were dissolved in methanol (350 mL) and at ambient temperature treated with sulfuric acid 97% (10.9 mL). The reaction mixture was stirred at 60° C. for 18 h. At 0° C. dichloro methane (500 mL) was added followed by aqueous sodium carbonate 10% (500 mL) (final pH 11) under vigorous stirring. The phases were separated. The aqueous phase was washed with dichloro methane, the combined organic phases with water and brine and then dried on sodium sulfate. After filtration and evaporation of the solvent the title product was obtained as a yellow oil (36.3 g, 98%) which was directly used in the next step. ES-MS m/e: 365.3 (M+H+).

Provenance & Evidence