Methylamine → HCID 68484747, compound

Participants

Reaction Conditions

Reaction Steps

Toluene-4-sulfonic acid (3R,4S)-1-benzyl-4-(3,4-dichloro-phenyl)-pyrrolidin-3-ylmethyl ester (5.0 g, 0.0102 mmol) were dissolved in 2.0 M solution of MeNH2 in THF (35 mL) in an autoclave and heated to 80° C. over night. The volatiles were removed and the crude product subjected to column chromatography (silica gel, dichloro methane/methanol 0->20%) to yield the title compound (3.25 g, 91%) as a light yellow oil.

Provenance & Evidence