HCID 86761696, compound → HCID 86761695, compound

Participants

Reaction Steps

To a solution of 1.14 g of 4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]benzyl alcohol in 20 mL of dichloromethane, 2.00 g of silica gel was added, and 0.80 g of pyridinium chlorochromate (PCC) was added to the resultant mixture while stirring the mixture at room temperature, followed by stirring the resultant mixture at the same temperature for 17 hours. After the completion of the reaction, the reaction mixture was passed through silica gel column chromatography eluting with ethyl acetate to obtain 0.97 g of a crude objective substance as a white solid. This substance was used in the next process as it was without being further purified.

Provenance & Evidence