Water → HCID 86761698, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4.28 g of 3-[3-bromo-5-(trifluoromethyl)phenyl]-1-(3-chloro-4-methylphenyl)-4,4,4-trifluoro-3-hydroxybutane-1-one in 10 mL of toluene, 2.08 g of thionyl chloride and 1.38 g of pyridine were added while stirring the solution at 80° C. to continue the stirring of the resultant mixture at the same temperature for 2 hours. After the completion of the reaction, 10 mL of water was added to the reaction mixture while ice-cooling the reaction mixture and the stirring of the reaction mixture was continued until the temperature of the reaction mixture returned to room temperature. The organic phase was separated off and charged into a solution of 0.77 g of sodium hydroxide in 5 mL of water. The resultant mixture was stirred at room temperature for 30 minutes. The organic phase was separated off and then was dehydrated and dried over saturated saline and anhydrous magnesium sulfate in this order. The solvent was distilled off under reduced pressure to obtain 4.02 g of a crude objective substance as a yellow oily substance. This substance was used in the next process as it was without being further purified.

Provenance & Evidence