Sodium Bicarbonate → HCID 86649764, compound

Participants

Reaction Steps

To a solution of 0.15 g of 3-(4-aminomethyl-3-chlorophenyl)-5-[3-bromo-5-(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazole and 0.083 g of (methylsulfonyl)acetic acid in 3 mL of dichloromethane, 0.11 g of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride was added and the resultant mixture was stirred at room temperature for 15 hours. After the completion of the reaction, the reaction mixture was diluted with 3 mL of chloroform, and then 3 mL of a saturated sodium hydrogen carbonate aqueous solution was added to the diluted reaction mixture, followed by separating off the organic phase. The separated organic phase was dehydrated and dried over saturated saline and anhydrous magnesium sulfate in this order. From the resultant organic phase, the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography eluting with ethyl acetate to obtain 0.14 g of the objective substance as a white crystal.

Provenance & Evidence