Diisopropyl Ether → 1,2-Dichloro-3-(trifluoromethyl)-5-[1-(trifluoromethyl)ethenyl]benzene

Temperature

-10 °C

In a nitrogen atmosphere, to a solution of 26.2 g of 5-bromo-2,3-dichlorobenzotrifluoride and 9.1 g of diisopropyl ether in 250 mL of hexane, 57.5 mL of an n-butyl lithium hexane solution (1.55 M) was gradually dropped while stirring the solution at −10° C. After the completion of the dropping, the resultant mixture was stirred at the same temperature for 30 minutes. Next, into the reaction mixture, a solution of 9.26 g of trimethoxyborane in 30 mL of tetrahydrofuran was dropped and the resultant mixture was continuously stirred at room temperature further for 10 minutes. To this reaction mixture, 150 mL of water, 23.4 g of 2-bromo-3,3,3-trifluoropropene, 36.9 g of potassium carbonate and 0.131 g of 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene(1,4-naphthoquinone) palladium (0) dimer were added and the resultant mixture was stirred at 60° C. for 4 hours. After the completion of the reaction, the reaction mixture was left to be cooled down to room temperature, and 50 mL of ice water and 75 mL of ethyl acetate were added to the reaction mixture, followed by separating off the insoluble substance and by cleaning the insoluble substance with 75 mL of ethyl acetate. The organic phase of the filtrate was separated off and the resultant organic phase was washed with water and then dehydrated and dried over saturated saline and anhydrous sodium sulfate in this order. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography eluting with hexane to obtain 21.8 g of the objective substance as a colorless oily substance.

1. customAfter the completion of the reaction
2. waitthe reaction mixture was left
3. temperatureto be cooled down to room temperature
4. customby separating off the insoluble substance
5. customThe organic phase of the filtrate was separated off
6. washthe resultant organic phase was washed with water
7. dry with materialdried over saturated saline and anhydrous sodium sulfate in this order
8. distillationThe solvent was distilled off under reduced pressure
9. customThe resultant residue was purified by silica gel column chromatography
10. washeluting with hexane
11. customto obtain 21.8 g of the objective substance as a colorless oily substance

ORD record

ord-0dbe75bce2ca4d1da0c2c4062977bee0

Source dataset

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08318757B2