Hydrochloric Acid → HCID 68912412, compound

Participants

Reaction Steps

Water (50 ml) and concentrated hydrochloric acid (50 ml) are added to N-(6-{3-[4-(benzylthio)phenyl]-1,2,4-oxadiazol-5-yl}pyridin-2-yl)acetamide (40.55 g) in ethanol (150 ml). The reaction mixture is heated under reflux until the starting material has reacted completely (about 3 h) and subsequently cooled to room temperature. The solid is collected by filtration, washed three times with ethanol and dried in a vacuum oven at 80° C. 36.60 g (92% of theory) of product are obtained as a solid.

Provenance & Evidence